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Piwi proteins and their guiding small RNAs, termed Piwi-interacting pi- RNAs, are essential for silencing of transposons in the germline of animals. Substantial research is going on to reveal the functions of piRNAs in the epigenetic and post-transcriptional regulation of transposons and genes. To collect and annotate these data, Freee developed piRBase, a database assisting piRNA functional study.

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